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Hypoglycaemia This is a rare and serious side effect

These symptoms may indicate peripheral vascular issues, particularly relevant for patients with diabetes who have increased cardiovascular risk

The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)

Semaglutide and berberine is another popular combination

Results vary, but many people notice appetite changes within the first few weeks